UNRESOLVED ORTHOLOGY AND PECULIAR CODING SEQUENCE PROPERTIES OF LAMPREY GENES: THE KCNA GENE FAMILY AS TEST CASE

Unresolved orthology and peculiar coding sequence properties of lamprey genes: the KCNA gene family as test case

Abstract Background In understanding the evolutionary process of vertebrates, cyclostomes (hagfishes and lamprey) occupy crucial positions.Resolving molecular phylogenetic relationships of cyclostome genes with gnathostomes (jawed vertebrates) genes is indispensable in deciphering both the species tree and gene trees.However, molecular phylogenetic

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PFKFB3 deprivation attenuates the cisplatin resistance via blocking its autophagic elimination in colorectal cancer cells

Introduction6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3) is highly expressed in several cancers and plays important roles during the whole pathological process of cancer.It is also involved in Drive Cable chemoresistance, while the intrinsic mechanism needs to be further revealed.MethodsThe different responses to cisplati

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